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KMID : 0390320120220010083
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Chungbuk Medical Journal
2012 Volume.22 No. 1 p.83 ~ p.95
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Species and Antimicrobial Susceptibility of Microorganisms Isolated from Blood Culture at a Chungbuk National University Hospital During 5 Years : 2005-2009
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Son Bo-Ra
Shin Kyeong-Seob
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Abstract
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Purpose: Analysis of the blood culture results can provide clinicians with the important information for the empirically antibiotic treatment of the patients with bacteremia. In this study, we analyzed the blood culture results of Chungbuk National University hospital during 5 years, retrospectively.
Materials and Methods: The blood culture results of Chungbuk National University hospital during the years 2005 to 2009 were analysed to determine the species and antimicrobial susceptibility of the isolate s. Blood culture bottles were incubated in the Bact/Alert 3D system (bioMerieux Inc., Durham, NC, US A), and then the isolates were identified by the VITEK II system. Antimicrobial susceptibility was tested by the VITEK II system (bioMerieux Inc., Hazelwood, MO, USA) or CLSI disk diffusion method.
Results: The number of positive blood culture was 3,632 (of 34,993, 10.4%). Among the microorganism s isolated from blood culture, 92.7% was aerobic and facultative anaerobic bacteria and 7.1% was fungi and the others were 0.2%. Frequently isolated organisms in decreasing order were coagulase negative sta phylococci (CNS, 26.5%), Escherichia coli (16.9%), Staphylococcus aureus (12.7%), Klebsiella pneumonia e (6.3%), Pseudomonas aeruginosa (2.2%). During 5 years, the isolation rate of methicillin-resistant S. a ureus (MRSA), penicillin-resistant Streptococcus pneumoniae (PRSP) and vancomcyin-resistant Enterococci (VRE) were increased. Moreover the proportion of extended-spectrum β-lactamase (ESBL) producers in E nterobacteriaceae were also increased. Multi-resistant P. aeruginosa and A. baumannii were significantly i ncreased, and the resistance against imipnem of A. baumannii was rapidly increased from 2007 years.
Conclusions: During 5 years, common etiologic microorganisms of bacteremia in decreasing order were E. coli, S. aureus and K. pneumoniae except CNS, commonly considering contaminants of skin. Isolatio n rates of MRSA, PRSP, VRE, ESBL, and multi-resistant glucose non-fermenting gram negative bacilli had been increased after 2005. It seems to be necessary to enhance infection control for multi-resistant microorganisms as well as to use the proper antibiotics by the antimicrobial susceptibility testing.
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KEYWORD
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Blood culture, Bacteremia, Species, Antimicrobial susceptibility testing
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